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e., Wdr77 is translocated with the nucleus in to the cytoplasm to generate proliferation of prostate cancer cells. With this research, we used in vivo genetic scientific studies to further more look into the part of Wdr77 in prostate tumorigenesis. We observed that prostate-unique deletion of Wdr77 abolished prostate tumor initiation induced by lack of the tumor suppressor Pten. Mechanistically, Wdr77 ablation inhibited E2F3 activation and Improved TGFβ signaling, resulting in attenuated cellular proliferation induced by lack of Pten. These conclusions create a important job of Wdr77 for prostate tumor initiation.
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